what causes high prolactin and its effects in females?

December 27, 2023by Dr. Shehrezad Czar0

Prolactin, a hormone produced by the pituitary gland, is crucial for lactation and has several other roles in the female body. Elevated levels of this hormone, a condition known as hyperprolactinemia, can have significant effects on women’s health, affecting menstrual function, fertility, and overall well-being. This article explores the causes of high prolactin in females and its wide-ranging effects.

Understanding Prolactin

It is primarily responsible for stimulating milk production after childbirth. However, its functions extend beyond lactation, playing roles in menstrual cycle regulation, fertility, and possibly influencing mood and immune function.

Causes of High Prolactin in Females

Prolactinomas: The most common cause of hyperprolactinemia is a benign tumor on the pituitary gland, known as a prolactinoma. These tumors produce excessive amounts of this hormone.

Medications: Certain medications, especially antipsychotics and some antidepressants, can increase its levels. Drugs used for high blood pressure and pain relief can also have this effect.

Hypothyroidism: Underactive thyroid (hypothyroidism) can lead to elevated prolactin levels. Thyroid hormones indirectly influence its secretion.

Pregnancy and Breastfeeding: Prolactin levels naturally increase during pregnancy and breastfeeding.

Other Pituitary Disorders: Conditions that affect the pituitary gland, such as hypopituitarism, can result in high prolactin.

Chest Wall Injury or Irritation: Nerve stimulation due to chest trauma, surgery, or shingles can lead to increased hormone production.

Idiopathic Hyperprolactinemia: In some cases, the cause of elevated levels remains unknown.

Effects of High Prolactin in Females

Menstrual Irregularities: High prolactin can disrupt the menstrual cycle, leading to irregular periods or amenorrhea (absence of menstruation).

Galactorrhea: This condition involves the production of breast milk in women who are not pregnant or breastfeeding.

Infertility: Elevated prolactin can interfere with ovulation, making it difficult to conceive.

Osteoporosis: Long-term effects of high prolactin can include reduced bone density, increasing the risk of osteoporosis.

Sexual Dysfunction: Women with high prolactin may experience reduced libido and vaginal dryness.

Mood Changes: There may be a link between high levels of this hormone and mood changes, including depression and anxiety, although more research is needed in this area.


Diagnosis typically involves:

Blood Tests: Measuring its levels through blood tests is the primary diagnostic method.

Physical Examination: A doctor will assess symptoms and medical history.

Imaging Tests: MRI scans of the pituitary gland are often performed if a prolactinoma is suspected.


Medications: Dopamine agonists are the first-line treatment for hyperprolactinemia, especially when caused by a prolactinoma. These medications help to reduce its production.

Treating Underlying Conditions: Addressing conditions like hypothyroidism can normalize prolactin levels.

Surgery or Radiation: In cases where a prolactinoma does not respond to medication, surgery or radiation therapy may be necessary.

Adjusting Medications: If a drug is elevating this hormone, adjusting the medication regimen can help.

Monitoring Bone Density: Women with long-standing high prolactin should have their bone density monitored to prevent osteoporosis.

Lifestyle Modifications

While medical treatment is primary, lifestyle factors can support overall health:

Regular Exercise: Can help in managing symptoms and improving bone health.

Adequate Calcium and Vitamin D Intake: Essential for bone health, especially in women at risk of osteoporosis.

Stress Management: Techniques like yoga, meditation, and counseling can help in managing stress-related implications of high prolactin.


High prolactin levels in females can have a profound impact on various aspects of health, from menstrual and reproductive function to mental well-being and bone health. Understanding the causes, recognizing the symptoms, and seeking appropriate treatment are crucial steps in managing this condition. With effective medical interventions and supportive lifestyle practices, women with hyperprolactinemia can lead healthy, fulfilling lives.

Also Read: How Is Growth Hormone Deficiency Diagnosed and Treated?

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