Unveiling the Role of CRH in Acromegaly: Corticotropin-Releasing

January 14, 2024by Dr. S. F. Czar0

Case Study:


Mark, a 38-year-old man, presented with a constellation of symptoms that had been progressively worsening over the past few years. He complained of a prominent forehead, enlarged hands and feet, joint pain, and a deepening voice. These symptoms raised suspicions of acromegaly, a rare hormonal disorder caused by excessive growth hormone (GH) production. This case study explores the involvement of Corticotropin-Releasing Hormone (CRH) in Mark’s acromegaly diagnosis and treatment.

Case Presentation:

Symptoms and Initial Assessment:

Mark’s journey began with subtle changes in his appearance and physical discomfort. Initially, he dismissed them as a natural part of aging. However, as the symptoms progressed, he decided to seek medical attention. His primary care physician ordered blood tests, including a GH measurement, insulin-like growth factor-1 (IGF-1) level, and an oral glucose tolerance test (OGTT).

The laboratory results revealed elevated GH and IGF-1 levels, suggesting acromegaly. To confirm the diagnosis and identify the source of GH overproduction, further investigations were warranted.

CRH Stimulation Test:

Mark’s endocrinologist decided to perform a CRH stimulation test to differentiate between pituitary and ectopic sources of GH production. This test involved administering synthetic CRH intravenously and monitoring GH responses.

During the test, Mark exhibited an exaggerated GH response, indicating that the source of GH overproduction was within the pituitary gland. This finding suggested a GH-secreting pituitary adenoma, the most common cause of acromegaly.

CRH and GH Regulation:

The endocrinologist explained to Mark the role of CRH in GH regulation. CRH receptors are expressed on pituitary somatotroph cells, which produce GH. CRH can directly stimulate GH secretion, particularly under stress conditions.

Mark disclosed that he had been experiencing chronic work-related stress for several years. The endocrinologist hypothesized that elevated CRH levels due to chronic stress might have contributed to the exacerbation of his acromegalic symptoms.

Treatment and Stress Management:
  • Medical Treatment: Mark was started on medical treatment with a somatostatin analog (SSA) to reduce GH secretion. This treatment aimed to lower GH levels and mitigate the physical changes and health risks associated with acromegaly.
  • Stress Management: Recognizing the potential impact of chronic stress on Mark’s condition, he was referred to a stress management program. The program included stress reduction techniques such as mindfulness meditation, relaxation exercises, and counseling to help him cope with stress effectively.
Follow-Up and Progress:

For several months, Mark’s GH levels gradually decreased in response to the medical treatment. Simultaneously, he diligently practiced stress reduction techniques and reported feeling more in control of his stressors.

Mark’s forehead prominence reduced, joint pain improved, and his voice reverted to its previous tone. Regular follow-up appointments and hormonal assessments ensured the effectiveness of his treatment plan.


Mark’s case highlights the involvement of CRH in acromegaly and the potential influence of chronic stress on the progression of the condition. By recognizing the role of CRH in GH regulation and addressing the stress component, healthcare providers can offer a more comprehensive approach to managing acromegaly. This approach combines medical therapies with stress management strategies to improve the quality of life for individuals affected by the disorder. Further research in this field may provide additional insights into the interplay between stress, hormones, and pituitary tumors.


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