“Parathormone’s Pivotal Role in Hyperparathyroidism: Unraveling the Hormonal Imbalance

January 26, 2024by Dr. S. F. Czar0


Patient Profile: Ms. A, a 54-year-old female, presented to the endocrinology clinic with complaints of persistent fatigue, bone pain, and occasional episodes of muscle weakness. Further investigation revealed elevated serum calcium levels during a routine health check, prompting a thorough evaluation for hyperparathyroidism.

Medical History: Ms. A had a history of chronic kidney disease (Stage 3), and her medications included antihypertensive agents and a thiazide diuretic for hypertension. This medical history raised suspicions about secondary hyperparathyroidism due to renal impairment and the potential impact of medications on calcium metabolism.

Clinical Presentation: Clinical examination revealed no overt signs of hypercalcemia, but laboratory tests demonstrated consistently elevated serum calcium levels along with increased parathormone (PTH) levels. Bone mineral density (BMD) scans indicated reduced bone density, further raising concerns about skeletal complications associated with prolonged hyperparathyroidism.

Diagnostic Journey:

  1. Laboratory Investigations:
    • Serum calcium levels consistently above the normal range.
    • Elevated PTH levels, indicating the involvement of the parathyroid glands.
    • Vitamin D levels within the lower normal range, highlighting a potential contributing factor.
  2. Imaging Studies:
    • Ultrasound and sestamibi scintigraphy confirmed the presence of an enlarged parathyroid gland, supporting the diagnosis of hyperparathyroidism.
    • Dual-energy X-ray absorptiometry (DEXA) scans revealed decreased bone mineral density, emphasizing the impact on skeletal health.

Diagnosis: The cumulative evidence pointed towards a diagnosis of secondary hyperparathyroidism, driven by chronic kidney disease and exacerbated by thiazide diuretic use. The enlarged parathyroid gland suggested hyperplasia as a response to persistent calcium imbalance.

Treatment Plan:

  1. Medical Management:
    • Initiation of active vitamin D analogs to address the deficiency and improve calcium absorption.
    • Modification of thiazide diuretic dosage to minimize its impact on calcium metabolism.
  2. Lifestyle Modifications:
    • Dietary counseling to ensure adequate calcium intake.
    • Encouraging moderate sun exposure for natural vitamin D synthesis.
  3. Close Monitoring:
    • Regular follow-up visits with laboratory assessments to monitor serum calcium, PTH, and vitamin D levels.
    • Periodic DEXA scans to assess bone density and response to treatment.


  1. Stabilization of Calcium Levels:
    • With the adjustment of medications and lifestyle modifications, Ms. A’s serum calcium levels gradually returned to the normal range.
  2. Improvement in Symptoms:
    • Fatigue and bone pain significantly reduced, enhancing Ms. A’s overall quality of life.
  3. Bone Health Preservation:
    • Subsequent DEXA scans revealed stabilization and improvement in bone mineral density, mitigating the risk of fractures and osteoporosis.


  1. Genetic and Environmental Factors:
    • Despite the absence of a genetic predisposition in Ms. A’s case, the interplay between chronic kidney disease, thiazide diuretic use, and vitamin D deficiency underscored the influence of environmental factors.
  2. Precision Medicine and Future Perspectives:
    • Genetic screening was not indicated in this case, but ongoing research on genetic mutations associated with primary hyperparathyroidism holds promise for future diagnostic and therapeutic advancements.
  3. Collaborative Approach:
    • The case emphasizes the importance of a multidisciplinary approach involving endocrinologists, nephrologists, and dietitians to address the diverse aspects of hyperparathyroidism.


Ms. A’s case exemplifies the intricate nature of hyperparathyroidism and the necessity of a comprehensive diagnostic and therapeutic approach. By unraveling the hormonal imbalances through meticulous investigation and tailored interventions, her condition was successfully managed, showcasing the potential for positive outcomes in the realm of hyperparathyroidism. Continued research and advancements in understanding the molecular mechanisms involved hold the key to refining treatment strategies and improving the lives of individuals grappling with this complex endocrine disorder.


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