how does prolactin affect fertility and pregnancy?

December 27, 2023by Dr. Shehrezad Czar0

Prolactin, a hormone produced by the pituitary gland, is widely recognized for its role in lactation. However, its influence extends to various aspects of reproductive health, including fertility in both men and women. Abnormal levels of this hormone can disrupt reproductive processes, leading to challenges in conceiving. This article explores the complex relationship between prolactin and fertility, shedding light on how this hormone affects reproductive functions and the management of related fertility issues.

Introduction to Prolactin

It is a peptide hormone primarily associated with breast milk production post-childbirth. Besides lactation, it plays a vital role in menstrual cycle regulation, immune response, and metabolic processes. In the context of fertility, its balance is crucial for optimal reproductive health.

Role in Reproductive Health

In Women:

Menstrual Cycle Regulation: It influences the menstrual cycle by interacting with hormones like estrogen and progesterone. It is involved in the luteal phase of the menstrual cycle and helps maintain the corpus luteum, which is crucial for pregnancy.

Impact on Ovulation: Elevated levels can interfere with ovulation, leading to irregular menstrual cycles or anovulation (absence of ovulation), impacting fertility.

In Men:

Testosterone Production: It affects the production of testosterone, an essential hormone for sperm production.

Sperm Health: Abnormal prolactin levels can lead to decreased sperm count, reduced sperm motility, and issues with sperm development.

Causes of Imbalance

Prolactinomas: Benign tumors on the pituitary gland, known as prolactinomas, are a common cause of elevated prolactin levels.

Medications: Certain drugs, particularly antipsychotics and antidepressants, can increase its levels.

Hypothyroidism: Underactive thyroid function can lead to increased production of  this hormone.

Other Health Conditions: Chronic kidney disease, liver disease, and other pituitary disorders can affect its levels.

Idiopathic Hyperprolactinemia: In some cases, the cause of high levels is unknown.

Effects of High Prolactin on Fertility

Female Fertility Issues: Elevated levels can lead to irregular menstrual cycles, making it difficult to predict ovulation. It can also cause anovulation, directly impacting a woman’s ability to conceive.

Male Fertility Challenges: In men, high prolactin can lead to hypogonadism, characterized by low testosterone levels, affecting sperm production and health.

Diagnosing Prolactin-Related Fertility Issues

Blood Tests: Measuring its levels through blood tests is essential for diagnosis.

Physical Examination and History: A comprehensive evaluation of symptoms and medical history is conducted.

Imaging Studies: MRI of the pituitary gland is often performed if a prolactinoma is suspected.


Dopamine Agonists: These medications, such as bromocriptine and cabergoline, are effective in reducing its levels and shrinking prolactinomas.

Treating Underlying Conditions: Addressing hypothyroidism or adjusting medications causing high prolactin can restore hormonal balance.

Surgical Intervention: In rare cases, surgery may be required to remove a prolactinoma.

Managing this hormone for Optimal Fertility

Regular Monitoring: Regular blood tests to monitor its levels are crucial for those with known imbalances.

Lifestyle Modifications: Stress reduction, a healthy diet, and regular exercise can support overall hormonal balance.

Fertility Treatment: In some cases, fertility treatments may be necessary alongside managing its levels.

Prolactin and Pregnancy

Once pregnancy is achieved, its levels naturally increase to prepare the body for breastfeeding. However, in women with prolactinomas, careful monitoring is needed to manage the tumor’s potential growth during pregnancy.


It plays a significant role in fertility for both men and women. Its imbalance, particularly hyperprolactinemia, can lead to various reproductive challenges. Understanding the impact of this hormone on fertility is crucial for individuals facing fertility issues. Through effective diagnosis and management of hormone levels, many of these challenges can be overcome, paving the way for successful conception and healthy pregnancy.

Also Read: how growth hormone helps in height and muscle growth?

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