Cortisol and Thyroid Hormones in Thyroid Dysfunction

January 14, 2024by Dr. S. F. Czar0

Case Study :

Patient Profile:

Name: Emma

Age: 38

Gender: Female

Chief Complaint:

Emma, a 38-year-old woman, presented to her endocrinologist with a history of unexplained weight gain, fatigue, and mood changes over the past year. She also mentioned persistent hair loss and cold intolerance, which had progressively worsened. Emma had a family history of autoimmune thyroid disorders.

Case Presentation:

History and Initial Assessment:

Emma reported a gradual onset of symptoms, including substantial weight gain, despite maintaining her usual diet and exercise routine. She also experienced severe fatigue, frequent mood swings, and difficulty concentrating. Her hair had become noticeably thinner, and she had developed an intolerance to cold temperatures. These symptoms prompted her to seek medical attention.

Physical Examination:

During the physical examination, the endocrinologist observed clinical signs suggestive of hypothyroidism, including dry skin, brittle nails, and a diffuse swelling of the thyroid gland (goiter). Emma’s vital signs included a low body temperature, bradycardia (slow heart rate), and elevated blood pressure.

Laboratory Investigations:

Blood tests were ordered to assess Emma’s hormonal profile. The results revealed:

  • Elevated thyroid-stimulating hormone (TSH) levels indicate primary hypothyroidism.
  • Low levels of free thyroxine (fT4), confirm an underactive thyroid gland.
  • Elevated cortisol levels, particularly in the morning, are indicative of a possible stress response.
  • Elevated anti-thyroid peroxidase (anti-TPO) antibodies suggest an autoimmune etiology for her thyroid dysfunction.
Diagnosis and Treatment:


  • Emma was diagnosed with primary hypothyroidism, most likely due to autoimmune thyroiditis (Hashimoto’s disease), given her family history and the presence of anti-TPO antibodies.
Cortisol Dysregulation:
  • The elevated cortisol levels, especially in the morning, raised concerns about a possible cortisol dysregulation. Emma’s medical history revealed chronic stress at work and significant life changes in recent years.
Levothyroxine Therapy:
  • To address her hypothyroidism, Emma was started on levothyroxine, a synthetic thyroid hormone replacement. The dose was adjusted gradually to achieve euthyroidism.
Stress Management:
  • Emma was referred to a stress management program, which included counseling, relaxation techniques, and lifestyle modifications to reduce stress levels.
Outcome and Progress:

Over several months of treatment, Emma’s thyroid function gradually improved. Her TSH and fT4 levels normalized, and her thyroid gland size reduced. Her symptoms of fatigue, cold intolerance, and hair loss improved significantly. Emma continued to practice stress management techniques and reported feeling more resilient to stressors.


Emma’s case highlights the intricate relationship between cortisol and thyroid hormones in the context of thyroid dysfunction. Chronic stress and cortisol dysregulation can exacerbate thyroid disorders, particularly autoimmune thyroiditis. A holistic approach, including appropriate thyroid hormone replacement therapy and stress management, is essential for individuals with thyroid dysfunction. This case underscores the importance of addressing both hormonal imbalances and stress factors to improve the overall well-being of patients with thyroid disorders.

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