Cholecystokinin Supplementation in Polycystic Ovary Syndrome Management

January 14, 2024by Dr. S. F. Czar0

Case Study: 

Patient Profile:

  • Name: Jessica Brown (hypothetical)
  • Age: 29 years
  • Medical History: Diagnosed with Polycystic Ovary Syndrome, struggling with irregular menstrual cycles, insulin resistance, and obesity.

Clinical Presentation:

  • Symptoms: Infrequent menstruation, hirsutism (excess hair growth), acne, and recent weight gain.
  • Laboratory Findings: Elevated androgens, insulin resistance indicated by high fasting insulin and glucose levels, and polycystic ovaries observed in ultrasound.
  • Diagnosis: Polycystic Ovary Syndrome with associated metabolic syndrome.

Treatment Plan:

  • Standard PCOS Management:
    • Prescription of metformin for insulin resistance.
    • Birth control pills to regulate menstrual cycles and manage androgen levels.
  • Cholecystokinin Supplementation:
    • Introduction of CCK-based supplements, hypothesized to improve insulin sensitivity and aid in weight management through appetite regulation.
  • Lifestyle Interventions:
    • Dietary modifications focusing on a balanced, low-glycemic diet.
    • Regular exercise regimen to promote weight loss and improve metabolic health.

Follow-Up and Monitoring:

  • Metabolic Parameters Assessment: Regular monitoring of fasting blood glucose, insulin levels, and lipid profile to assess metabolic control.
  • Menstrual and Reproductive Health Tracking: Evaluation of menstrual regularity and symptoms related to PCOS.
  • Weight and Appetite Monitoring: Ongoing assessment of weight changes and appetite control to evaluate the effectiveness of CCK supplementation.


  • Short-term: After 6 months, Jessica reports improved control over her appetite and a modest weight loss. Her fasting insulin levels show improvement, and she experiences a more regular menstrual cycle.
  • Long-term Management: Continued management of PCOS with a focus on maintaining metabolic health, optimizing CCK supplementation, and sustaining lifestyle changes.


This case study explores the innovative use of Cholecystokinin supplementation in the comprehensive management of Polycystic Ovary Syndrome. While the primary treatment focuses on addressing insulin resistance and hormonal imbalances, the addition of CCK aims to assist in weight management and improve insulin sensitivity. This integrated approach could potentially offer a more effective management strategy for PCOS, addressing both the metabolic and reproductive aspects of the condition.


Jessica’s case underscores the potential benefits of incorporating emerging therapeutic approaches like CCK supplementation into traditional PCOS treatment plans. It highlights the importance of considering both metabolic and hormonal factors in managing PCOS and suggests that CCK supplementation could be a promising addition to PCOS treatment strategies. This case also emphasizes the need for ongoing research to fully understand the role of CCK in PCOS and to validate the efficacy of such integrative treatment strategies.

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