Cholecystokinin Supplementation in Cushing’s Syndrome Management

January 14, 2024by Dr. S. F. Czar0

Case Study: 

Patient Profile:

  • Name: Sarah Mitchell (hypothetical)
  • Age: 42 years
  • Medical History: Diagnosed with Cushing’s Syndrome due to an adrenal adenoma, presenting with weight gain, muscle weakness, and uncontrolled hypertension.

Clinical Presentation:

  • Symptoms: Sarah has experienced a rapid and significant weight gain, particularly in the abdominal area. She has also noticed muscle weakness and bruising easily. Her blood pressure has become difficult to control.

Diagnosis and Treatment Plan:

  • Diagnosis of Cushing’s Syndrome:
    • Extensive hormonal testing and imaging studies, including a CT scan, confirmed the presence of an adrenal adenoma causing excess cortisol production.
  • Standard Cushing’s Syndrome Management:
    • Sarah underwent surgical removal of the adrenal adenoma (adrenalectomy) to normalize cortisol levels.
  • Cholecystokinin Supplementation:
    • As part of an experimental treatment approach, Sarah’s endocrinologist recommended CCK-based supplements to aid in cortisol regulation and metabolic improvements post-surgery.

Follow-Up and Monitoring:

  • Hormonal Assessment: Regular assessment of cortisol levels to ensure they remain within the normal range post-surgery and during CCK supplementation.
  • Metabolic Parameters Monitoring: Evaluation of insulin sensitivity, glucose metabolism, and weight changes to assess the impact of CCK supplementation.


  • Short-term: Following the adrenalectomy and initiation of CCK supplementation, Sarah’s cortisol levels gradually return to normal. She experiences improvements in muscle strength, and her blood pressure becomes more manageable.
  • Long-term: Over the next few years, Sarah will continue with CCK supplementation as part of her post-operative care. Her metabolic parameters remain stable, and she maintains a healthy weight.


This case study explores the experimental use of Cholecystokinin supplementation as an adjunct therapy in managing Cushing’s Syndrome, particularly in a patient post-adrenalectomy. While the primary treatment approach involves surgical removal of the adrenal adenoma to normalize cortisol levels, the addition of CCK aims to optimize metabolic aspects and improve overall health post-surgery.


Sarah’s case highlights the potential benefits of incorporating innovative therapeutic approaches like CCK supplementation into traditional Cushing’s Syndrome treatment plans. It emphasizes the importance of not only addressing excess cortisol but also optimizing metabolic parameters and overall health in individuals recovering from Cushing’s Syndrome. Further research and clinical trials are essential to validate the efficacy and safety of CCK-based therapies in post-operative Cushing’s Syndrome management, ensuring that it becomes a valuable addition to the treatment options for this complex endocrine disorder.

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