Case Study: HPL and Acromegaly pregnancy

January 4, 2024by Dr. S. F. Czar0

Patient Profile:

  • Name: Maria
  • Age: 32
  • Gestational Age: 26 weeks
  • Medical History: Maria has a history of acromegaly due to a pituitary adenoma and has been undergoing medical treatment to control her GH levels.

Clinical Presentation:

  • Symptoms: During her second trimester of pregnancy, Maria experienced an increase in acromegaly-related symptoms, such as enlarged hands and feet, joint pain, and facial changes.

Diagnostic Workup:

Given Maria’s medical history and her worsening acromegaly symptoms during pregnancy, her healthcare provider conducted an extensive evaluation:

  • Hormonal Assessment: Hormonal tests were performed, including measurements of GH, IGF-1 (Insulin-like Growth Factor 1), and HPL levels.
  • Imaging: An MRI of the pituitary gland was conducted to assess the status of her pituitary adenoma.


Based on the diagnostic workup, Maria’s healthcare provider confirmed the exacerbation of her acromegaly symptoms during pregnancy.


This case study highlights the role of HPL in the context of acromegaly during pregnancy:

1. Clinical Presentation:

  • Maria’s worsening acromegaly-related symptoms during pregnancy raised concerns about the hormonal changes associated with gestation.

2. Hormonal Monitoring:

  • Comprehensive hormonal assessments, including HPL levels, were essential in diagnosing the exacerbation of acromegaly symptoms.

3. Treatment Adjustments:

  • Maria’s healthcare provider made adjustments to her medication regimen, considering the presence of HPL during pregnancy, to control her GH levels and manage her symptoms.

4. Maternal and Fetal Health:

  • Close monitoring of both Maria’s health and fetal well-being was crucial to prevent complications related to acromegaly during pregnancy.


  • Maria’s healthcare team successfully managed the exacerbation of her acromegaly symptoms during pregnancy through adjustments to her treatment plan.
  • Regular monitoring ensured that her hormonal levels remained within the desired range, reducing the risk of complications for both her and her baby.


Maria’s case illustrates the significance of recognizing the potential impact of HPL on acromegaly during pregnancy. By understanding the hormonal complexities involved, healthcare providers can tailor treatment approaches, monitor patients effectively, and offer insights into the management of acromegaly symptoms during pregnancy. This case also underscores the importance of multidisciplinary care and patient education to optimize the health and well-being of individuals with acromegaly during this unique life stage.

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