Case Study: Hepcidin Dysregulation in Hyperparathyroidism

January 27, 2024by Dr. S. F. Czar0

Case Study: Hepcidin Dysregulation in Hyperparathyroidism

Patient Profile:

  • Name: Sarah
  • Age: 55
  • Gender: Female
  • Medical History: Sarah has been diagnosed with primary hyperparathyroidism for the past five years. She has been managed with medical therapy, including calcimimetics to control her hypercalcemia.
  • Presenting Complaint: Sarah reports persistent fatigue, muscle weakness, and shortness of breath. She mentions that her skin appears paler than usual.

Clinical Presentation:

  • Physical Examination: Sarah appears pale, and her skin has a slightly yellowish tint. She exhibits muscle weakness and reduced muscle mass. There is no significant height loss or bone deformities.
  • Blood Work: Sarah’s blood tests show elevated serum calcium levels and elevated parathyroid hormone (PTH) levels, consistent with her hyperparathyroidism diagnosis. Additionally, her serum ferritin levels are significantly reduced, indicating iron deficiency. Hepcidin levels are measured and found to be elevated.


Based on Sarah’s clinical presentation and laboratory results, she is diagnosed with primary hyperparathyroidism and iron deficiency anemia. The coexistence of these conditions raises suspicions of hepcidin dysregulation.


Hepcidin dysregulation in primary hyperparathyroidism can be explained as follows:

1. Impact of Hypercalcemia:

  • Influence on Iron Absorption: Hypercalcemia, a hallmark of hyperparathyroidism, can affect intestinal iron absorption. Elevated calcium levels may lead to reduced iron absorption, exacerbating iron deficiency.
  • Hepcidin Dysregulation: Hypercalcemia may indirectly influence hepcidin production, leading to elevated hepcidin levels. Increased hepcidin levels can further contribute to reduced iron absorption and release from stores.

2. Iron Deficiency Anemia:

  • Symptoms: Sarah’s symptoms of fatigue, muscle weakness, and shortness of breath are consistent with iron deficiency anemia, a condition characterized by insufficient iron levels for proper red blood cell production and function.

Treatment and Management:

Sarah’s treatment plan includes:

1. Hyperparathyroidism Management:

  • Continuing with medical therapy, including calcimimetics and monitoring serum calcium and PTH levels to control her hypercalcemia and prevent complications.

2. Iron Supplementation:

  • Initiating iron supplementation to correct the iron deficiency anemia. Iron supplementation should be tailored based on laboratory assessments, considering both iron status and hepcidin regulation.

3. Regular Monitoring:

  • Frequent monitoring of iron parameters, including serum ferritin, hemoglobin, and hepcidin levels, to assess the effectiveness of iron supplementation and make necessary adjustments.


This case study highlights the potential impact of hepcidin dysregulation in individuals with primary hyperparathyroidism. Understanding the complex interactions between hypercalcemia, iron regulation, and anemia is crucial in managing this endocrine disorder effectively. Tailored treatment strategies that address both hyperparathyroidism and iron balance are essential for improving the health and well-being of patients like Sarah..

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