Calcitriol Supplementation in the Management of Acromegaly

January 14, 2024by Dr. S. F. Czar0

Case Study: 

Patient Profile:

  • Name: Mark Johnson (hypothetical)
  • Age: 48 years
  • Medical History: Recently diagnosed with acromegaly due to a pituitary adenoma, history of hypertension, and newly identified vitamin D deficiency.

Clinical Presentation:

  • Symptoms: Enlarged hands and feet, prominent jaw, joint pain, fatigue, and episodes of headaches.
  • Laboratory Findings: Elevated levels of growth hormone (GH) and insulin-like growth factor 1 (IGF-1), hypertension, impaired glucose tolerance, and low vitamin D levels.
  • Diagnosis: Acromegaly with co-existing vitamin D deficiency.

Treatment Plan:

  • Surgical and Pharmacological Intervention:
    • Transsphenoidal surgery for the removal of the pituitary adenoma.
    • Post-surgical medical therapy with a somatostatin analog to control GH and IGF-1 levels.
  • Calcitriol Supplementation:
    • Initiation of calcitriol supplementation to address vitamin D deficiency, with the potential to support bone health and improve metabolic outcomes.
  • Lifestyle Modifications:
    • Dietary counseling focusing on a balanced diet and managing glucose levels.
    • Encouragement of regular, moderate physical activity to improve cardiovascular health and joint function.

Follow-Up and Monitoring:

  • Hormonal Monitoring: Regular assessments of GH and IGF-1 levels to gauge the effectiveness of the treatment.
  • Vitamin D Status: Monitoring of vitamin D levels and adjusting calcitriol dosage as needed.
  • Symptomatic Evaluation: Ongoing assessment of symptoms related to acromegaly and side effects of treatments.


  • Short-term: Post-surgery, Mark shows a significant reduction in GH and IGF-1 levels. Vitamin D levels normalize with calcitriol supplementation, and there’s a noticeable improvement in joint pain and energy levels.
  • Long-term Management: Continued monitoring of hormonal levels, vitamin D status, and overall health. The focus remains on managing any long-term complications of acromegaly.


This case study illustrates the potential benefits of incorporating calcitriol supplementation in the treatment regimen for acromegaly, particularly in patients with vitamin D deficiency. The adjunctive use of calcitriol, in conjunction with surgical and pharmacological interventions, may offer additional benefits in terms of bone health, metabolic regulation, and quality of life.


Mark’s case underscores the importance of a comprehensive approach to managing acromegaly, which includes addressing coexisting conditions such as vitamin D deficiency. It demonstrates the potential role of calcitriol in enhancing the overall management of acromegaly, suggesting a promising area for further research and clinical application. This case also highlights the need for personalized care plans, taking into account the multifaceted nature of acromegaly and its associated comorbidities.

Calcitriol Supplementation in a Patient with PCOS(hormones)

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