Calcitriol Supplementation in a Patient with PCOS(hormones)

January 14, 2024by Dr. S. F. Czar0

Case Study: 

Patient Profile:
  • Name: Emily Johnson (hypothetical)
  • Age: 32 years
  • Medical History: Diagnosed with PCOS three years ago, overweight, insulin resistant, and has a history of irregular menstrual cycles.
Clinical Presentation:
  • Symptoms: Emily experiences irregular periods, hirsutism, and struggles with weight management. She also reports fatigue and occasional mood swings.
  • Laboratory Findings: Elevated androgen levels, insulin resistance indicated by HOMA-IR (Homeostatic Model Assessment for Insulin Resistance), and Vitamin D deficiency.
  • Diagnosis: PCOS with insulin resistance and Vitamin D deficiency.
Treatment Plan:
  • Lifestyle Modifications:
    • Emily is advised to adopt a balanced diet rich in nutrients and low in simple carbohydrates. Regular physical activity is recommended to aid in weight management and improve insulin sensitivity.
  • Insulin Sensitizers:
    • Metformin is prescribed to manage insulin resistance, a common feature in PCOS.
  • Calcitriol Supplementation:
    • Due to her Vitamin D deficiency and its potential implications in PCOS, Emily is started on calcitriol supplementation.
    • The dosage is carefully calibrated to avoid risks such as hypercalcemia.
  • Hormonal Treatments:
    • Oral contraceptives are prescribed to regulate menstrual cycles and manage hyperandrogenism.
Follow-Up and Monitoring:
  • Regular Blood Tests: Monitoring of blood glucose levels, hormone profiles, and Vitamin D levels every 2-3 months.
  • Symptom Tracking: Regular assessments of menstrual regularity, hirsutism, and overall well-being.
  • Weight Management: Tracking progress in weight loss and metabolic health.
  • Short-term: After six months, Emily reports an improvement in menstrual regularity and a reduction in hirsutism. Blood tests show normalized Vitamin D levels and improved insulin sensitivity.
  • Long-term Management: Continued monitoring and adjustment of calcitriol dosage, along with ongoing lifestyle modifications and hormonal treatments.

This case study illustrates the potential benefits of calcitriol supplementation in managing certain aspects of PCOS, particularly in a patient with Vitamin D deficiency and insulin resistance. The integration of calcitriol with standard PCOS treatments and lifestyle changes can lead to improvements in hormonal balance, metabolic health, and overall quality of life.


Emily’s case highlights the importance of addressing Vitamin D deficiency in PCOS management and suggests the potential role of calcitriol in improving clinical outcomes. It underscores the need for a comprehensive, multidisciplinary approach to treating PCOS, considering each patient’s unique clinical presentation and response to treatment. This case also emphasizes the importance of regular monitoring and the need for ongoing research to further understand the role of calcitriol in PCOS management.

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