Cortisol and Insulin Sensitivity

January 15, 2024by Dr. S. F. Czar0

Case study:

Patient Profile:

Name: Michael

Age: 55

Gender: Male

Chief Complaint:

Michael, a 55-year-old man, presented to his endocrinologist’s office with a recent diagnosis of type 2 diabetes. He had been experiencing progressively worsening symptoms, including increased thirst, frequent urination, fatigue, and unexplained weight loss. Michael’s medical history revealed that he had a high-stress job, which had become more demanding over the past year.

Case Presentation:

History and Initial Assessment:

Michael reported a gradual onset of symptoms over several months. He had lost approximately 15 pounds despite not actively trying to lose weight, and he felt exhausted most of the time. He mentioned that his job had become increasingly stressful, leading to long working hours and disrupted sleep patterns.

Physical Examination:

During the physical examination, the healthcare provider noted signs of uncontrolled diabetes, including elevated blood pressure, increased thirst, and dry mouth. Michael’s body mass index (BMI) indicated that he was overweight, and his abdominal circumference suggested central obesity.

Laboratory Investigations:

Blood tests were ordered to assess Michael’s hormonal profile and glucose levels. The results revealed:

  • Elevated fasting blood glucose levels well above the diabetic range.
  • Elevated HbA1c levels indicate poor long-term glucose control.
  • Increased cortisol levels, especially in the morning, are indicative of chronic stress.
  • Elevated inflammatory markers suggest a pro-inflammatory state.
Diagnosis and Treatment:

Type 2 Diabetes:

  • Michael was diagnosed with type 2 diabetes based on his elevated fasting blood glucose and HbA1c levels. The healthcare provider explained the importance of blood glucose control to prevent complications.
Stress Management:
  • Given Michael’s high-stress job and elevated cortisol levels, stress management was a primary focus of his treatment plan. He was referred to a stress reduction program that included mindfulness meditation and relaxation techniques.
Lifestyle Modification:
  • Michael received guidance on making dietary changes and incorporating regular physical activity into his daily routine to address obesity and improve insulin sensitivity.
  • To achieve immediate blood glucose control, Michael was prescribed oral antidiabetic medications. His healthcare provider emphasized the importance of medication adherence and regular follow-up.
Outcome and Progress:

Over several months of treatment and stress management, Michael’s condition improved significantly. His blood glucose levels stabilized within the target range, and his HbA1c levels began to decrease. He reported feeling less fatigued and more in control of his diabetes. Additionally, his weight gradually started to normalize as he continued to focus on lifestyle modifications.


Michael’s case underscores the critical role of cortisol and stress in influencing insulin sensitivity in type 2 diabetes. Chronic stress can exacerbate insulin resistance and complicate glycemic control. An integrated approach that addresses not only glucose levels but also stress management and lifestyle modifications is essential for individuals with diabetes, particularly those with elevated cortisol levels due to stress. This case demonstrates the potential for improved outcomes when healthcare providers consider the hormonal perspective in diabetes management.

Susan Martinez and Hormonal Blood Pressure Dysregulation

Role of Endocrinologists in Your Well-being

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