Case Study: The Impact of hCG on Thyroid Dysfunction

January 27, 2024by Dr. S. F. Czar0

Case Study: The Impact of hCG on Thyroid Dysfunction

Patient Profile:

  • Name: Mary
  • Age: 32
  • Gender: Female
  • Medical History: Mary has a history of irregular menstrual cycles and difficulty conceiving. She recently became pregnant.
  • Presenting Complaint: Mary experiences fatigue, weight gain, and cold intolerance during her first trimester of pregnancy.

Clinical Presentation:

  • Physical Examination: Mary appears tired, with dry skin and brittle nails. Her weight has increased, and she exhibits a puffy appearance. Her vital signs are within normal limits.
  • Initial Laboratory Tests: Mary’s thyroid function tests reveal elevated levels of thyroid-stimulating hormone (TSH) and low levels of free thyroxine (FT4), consistent with hypothyroidism.

Diagnostic Workup:

Given Mary’s symptoms and thyroid function test results, further investigations are conducted:

  • hCG Levels: Mary’s hCG levels are measured and found to be significantly elevated, as expected during pregnancy.


Based on Mary’s clinical presentation, thyroid function tests, and elevated hCG levels, she is diagnosed with pregnancy-induced hypothyroidism.


This case study illustrates the interplay between hCG and thyroid dysfunction during pregnancy:

1. Pregnancy-Induced Hypothyroidism:

  • Mary’s elevated hCG levels during pregnancy stimulate the thyroid gland, leading to an increase in thyroid hormones. However, in some cases, such as hers, the thyroid may not respond adequately, resulting in hypothyroidism.

2. Clinical Presentation:

  • Mary’s symptoms of fatigue, weight gain, and cold intolerance are typical of hypothyroidism. Pregnancy can exacerbate these symptoms due to the increased demand for thyroid hormones.

3. Monitoring and Management:

  • Mary’s healthcare provider initiates thyroid hormone replacement therapy to normalize her thyroid function and manage her symptoms. Regular monitoring of thyroid hormones and hCG levels is essential to ensure optimal thyroid health during pregnancy.


Mary’s case highlights the role of hCG in thyroid dysfunction during pregnancy. Understanding the complex interactions between hCG and the thyroid gland is crucial for diagnosing and managing pregnancy-induced thyroid disorders effectively. Timely intervention ensures the well-being of both the mother and the developing fetus.

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