Calcitriol Supplementation in Hyperprolactinemia Management

January 14, 2024by Dr. S. F. Czar0

Case Study: 

Patient Profile:

  • Name: Laura Anderson (hypothetical)
  • Age: 30 years
  • Medical History: Recently diagnosed with hyperprolactinemia, experiencing menstrual irregularities and infertility.

Clinical Presentation:

  • Symptoms: Irregular menstrual cycles, galactorrhea (milk production not associated with childbirth or nursing), and difficulty conceiving.
  • Laboratory Findings: Elevated serum prolactin levels, normal thyroid function tests, and low vitamin D levels.
  • Diagnosis: Idiopathic hyperprolactinemia with concurrent vitamin D deficiency.

Treatment Plan:

  • Pharmacological Intervention:
    • Dopamine agonists, such as cabergoline, are prescribed to lower prolactin levels.
  • Calcitriol Supplementation:
    • Given the low vitamin D levels and potential bone health concerns, calcitriol supplementation is initiated.
    • The dosage is carefully determined to avoid any risk of hypercalcemia.
  • Lifestyle and Dietary Modifications:
    • Dietary counseling to ensure adequate intake of calcium and vitamin D.
    • Regular weight-bearing exercises to promote bone health.

Follow-Up and Monitoring:

  • Prolactin Level Assessment: Regular monitoring of prolactin levels to gauge the effectiveness of cabergoline treatment.
  • Vitamin D Status: Frequent checks of vitamin D levels and adjusting calcitriol dosage as needed.
  • Reproductive Health Follow-up: Ongoing assessment of menstrual regularity and fertility status.


  • Short-term: After 3 months, Laura’s prolactin levels normalize, and menstrual regularity is restored. Vitamin D levels improve with calcitriol supplementation.
  • Long-term Management: Continued monitoring of hormonal levels and vitamin D status, with a focus on maintaining bone health and supporting fertility.


This case study illustrates the potential role of calcitriol supplementation in the comprehensive management of hyperprolactinemia, especially in patients with vitamin D deficiency. While the primary treatment with dopamine agonists directly addresses the elevated prolactin levels, the addition of calcitriol targets the associated risk of bone density loss and helps in normalizing vitamin D levels.


Laura’s case highlights the importance of a holistic approach in managing hyperprolactinemia, considering not just the hormonal imbalance but also associated nutritional deficiencies. The integration of calcitriol into her treatment plan demonstrates the potential benefits of addressing vitamin D status, suggesting a promising area for further clinical research and application. It also emphasizes the need for personalized care plans, taking into account the individual patient’s overall health status and response to treatment.

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