Hyperparathyroidism in Chronic Kidney Disease

January 8, 2024by Dr. S. F. Czar0

Case Study: Managing Secondary 

Patient Background:

  • Name: John Doe (hypothetical)
  • Age: 58 years
  • Medical History: Diagnosed with chronic kidney disease (CKD) stage 3b, hypertension, type 2 diabetes.
  • Current Issue: Recent blood tests indicate elevated PTH levels, consistent with secondary hyperparathyroidism, a common complication in CKD.

Clinical Presentation:

  • Symptoms: John reports increasing fatigue and occasional bone pain.
  • Laboratory Findings: Elevated PTH levels, slightly decreased calcium levels, increased phosphate levels, and reduced vitamin D levels.
  • Diagnosis: Secondary hyperparathyroidism due to CKD.

Treatment Plan:

  • Initiation of Calcitriol Therapy:
    • John is prescribed calcitriol to manage his elevated PTH levels. The aim is to increase calcium absorption, reduce PTH secretion, and avoid further bone demineralization.
    • Dosage is carefully determined to avoid hypercalcemia.
  • Dietary Modifications:
    • A diet low in phosphate is recommended to manage his phosphate levels.
    • Calcium intake is monitored to ensure it’s adequate but not excessive.
  • Additional Medications:
    • Phosphate binders are prescribed to control serum phosphate levels.
    • Continuation of his existing medications for CKD, hypertension, and diabetes.

Follow-Up and Monitoring:

  • Regular Blood Tests: Monitoring of serum calcium, phosphate, PTH, and kidney function tests every 2-3 months.
  • Bone Density Scans: Scheduled periodically to assess bone health.
  • Symptom Review: Regular consultations to monitor symptoms like bone pain or weakness.


  • Short-term: After 3 months, John’s PTH levels start to decrease, and his symptoms of fatigue and bone pain improve.
  • Long-term Management: Continued monitoring and adjustment of calcitriol dosage based on blood test results. Ongoing management of CKD, diabetes, and hypertension.


This case study demonstrates the complexity of managing secondary hyperparathyroidism in CKD. The successful use of calcitriol hinges on careful dosing and monitoring to avoid complications such as hypercalcemia. It also highlights the importance of a comprehensive approach, including dietary management and treatment of underlying conditions.


John’s case is a classic example of how calcitriol can be effectively used to manage PTH imbalances in the context of CKD. It underscores the importance of personalized treatment plans and the need for regular monitoring to ensure optimal outcomes.

Antagonistic Alchemy in Hyperparathyroidism

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