CRH and Its Impact: (Cholecystokinin)

January 27, 2024by Dr. S. F. Czar0

Case Study:


Hypothalamic amenorrhea is a condition characterized by the absence of menstrual periods due to disruptions in the hypothalamic-pituitary-ovarian axis. Stress is one of the known factors that can contribute to the development of hypothalamic amenorrhea, and corticotropin-releasing hormone (CRH) plays a significant role in the body’s stress response. This case study explores the relationship between CRH and hypothalamic amenorrhea through the story of Sarah, a 28-year-old woman who presented with amenorrhea.

Patient Profile:
  • Name: Sarah
  • Age: 28 years
  • Occupation: High-pressure job with long working hours
  • Medical History: No known prior medical conditions or menstrual irregularities
  • Lifestyle: Intense exercise regimen and a demanding work schedule
Presenting Complaint:

Sarah presented to her gynecologist with a primary complaint of missing her menstrual periods for the past six months. She reported previously regular menstrual cycles and no significant changes in her weight or diet. However, she mentioned that her work had become increasingly stressful over the past year.

Clinical Evaluation:

Upon clinical examination, Sarah was found to have no abnormalities in her physical exam, including no signs of polycystic ovary syndrome (PCOS). Laboratory tests confirmed the absence of pregnancy, and hormone levels revealed low levels of estradiol and progesterone, consistent with hypothalamic amenorrhea.

Treatment and Intervention:

Sarah’s gynecologist suspected that stress might be a contributing factor to her amenorrhea. Given her demanding job and intense exercise routine, it was hypothesized that elevated CRH levels might be impacting her hypothalamic-pituitary-ovarian axis. The following interventions were suggested:

  • Stress Management:

      Sarah was advised to incorporate stress management techniques into her daily routine. This included relaxation exercises, mindfulness, and counseling to help her cope with workplace stress.

  • Reduced Exercise:

     Sarah was encouraged to reduce the intensity and duration of her exercise routine to a level that would be less physically demanding on her body.

  • Nutritional Guidance:

A registered dietitian provided nutritional guidance to ensure that Sarah was consuming enough calories and nutrients to support her body’s reproductive functions.

Follow-up and Outcomes:

Sarah diligently followed the recommended interventions for several months. She noticed a gradual reduction in her stress levels and a more balanced work-life routine. After six months, her menstrual cycles resumed, and her hormone levels returned to normal. Sarah’s case highlighted the role of CRH in the pathogenesis of hypothalamic amenorrhea and the importance of addressing stress as part of the treatment plan.


This case study illustrates the potential connection between elevated CRH levels due to chronic stress and the development of hypothalamic amenorrhea. While it is essential to consider individual factors in each case, addressing stress and its impact on hormonal balance is crucial in the management of hypothalamic amenorrhea.


Hypothalamic amenorrhea is a complex condition with various contributing factors, and chronic stress, mediated in part by CRH, can be a significant player in its pathogenesis. This case study of Sarah underscores the importance of recognizing the role of stress and hormone regulation in diagnosing and treating hypothalamic amenorrhea. It also emphasizes the need for a holistic approach that includes stress management and lifestyle modifications in the treatment plan.

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