Cholecystokinin Supplementation in Type 2 Diabetes Management

January 14, 2024by Dr. S. F. Czar0

Case Study: 

Patient Profile:

  • Name: Michael Johnson (hypothetical)
  • Age: 55 years
  • Medical History: Recently diagnosed with Type 2 Diabetes Mellitus, overweight, and exhibiting signs of insulin resistance.

Clinical Presentation:

  • Symptoms: Frequent urination, increased thirst, fatigue, and unexplained weight loss.
  • Laboratory Findings: Elevated fasting blood glucose levels, HbA1c indicating poor glycemic control, and suboptimal lipid profile.
  • Diagnosis: Type 2 Diabetes Mellitus with associated metabolic syndrome.

Treatment Plan:

  • Standard Antidiabetic Therapy:
    • Initiation of metformin to improve insulin sensitivity and glucose uptake.
    • Dietary and lifestyle modifications focusing on a balanced diet and regular exercise.
  • Cholecystokinin Supplementation:
    • Introduction of a CCK-based supplement, hypothesized to enhance insulin secretion and improve satiety, leading to better dietary compliance.
  • Lifestyle and Dietary Modifications:
    • Emphasis on a diet rich in protein and fiber to naturally stimulate CCK production.
    • Encouragement of regular physical activity to aid in weight management and improve insulin sensitivity.

Follow-Up and Monitoring:

  • Glycemic Control Assessment: Regular monitoring of fasting blood glucose and HbA1c levels to assess the effectiveness of the treatment plan.
  • Appetite and Satiety Evaluation: Periodic assessment of appetite control and eating habits to determine the impact of CCK supplementation.
  • Metabolic Health Review: Continuous evaluation of weight, blood pressure, and lipid profiles.


  • Short-term: Within 3 months, Michael reports improved control over his eating habits and a modest weight loss. His blood glucose levels show improvement, and his HbA1c decreases slightly.
  • Long-term Management: Ongoing diabetes management with a focus on maintaining glycemic control, optimizing CCK supplementation, and sustaining lifestyle changes.


This case study illustrates the potential role of Cholecystokinin supplementation in complementing traditional management strategies for Type 2 Diabetes Mellitus. While standard therapies primarily focus on improving insulin sensitivity and glycemic control, the addition of CCK supplementation aims to enhance insulin secretion and support dietary compliance through improved satiety.


Michael’s case underscores the importance of a comprehensive approach to managing T2DM, which includes addressing both metabolic control and lifestyle factors. The integration of CCK supplementation into his treatment plan demonstrates the potential benefits of this novel approach, suggesting an area for further clinical research and application. It also emphasizes the need for personalized care plans, considering the individual patient’s metabolic profile, eating habits, and response to treatment.

Cholecystokinin Supplementation in Type 2 Diabetes Management

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