Case Study: Hepcidin Dysregulation in Polycystic Ovary Syndrome (PCOS

January 27, 2024by Dr. S. F. Czar0

Case Study: Hepcidin Dysregulation in Polycystic Ovary Syndrome (PCOS)

Patient Profile:

  • Name: Emily
  • Age: 30
  • Gender: Female
  • Medical History: Emily has been diagnosed with PCOS for the past five years. She has been managing her condition with lifestyle modifications and hormonal therapy.
  • Presenting Complaint: Emily reports persistent fatigue, irregular menstrual cycles, and hair loss.

Clinical Presentation:

  • Physical Examination: Emily exhibits signs of hirsutism (excessive hair growth) and alopecia (hair loss). Her skin appears mildly pale. There are no significant abnormalities in her physical examination.
  • Blood Work: Emily’s blood tests reveal elevated levels of androgens, consistent with her PCOS diagnosis. Additionally, her serum ferritin levels are significantly reduced, indicating iron deficiency. Hepcidin levels are measured and found to be elevated.


Based on Emily’s clinical presentation and laboratory results, she is diagnosed with PCOS and iron deficiency anemia. The elevated hepcidin levels suggest hepcidin dysregulation as a potential contributor to her anemia.


Hepcidin dysregulation in PCOS can be explained as follows:

1. Impact of Hormonal Imbalances:

  • Hyperandrogenism: PCOS is characterized by hyperandrogenism, leading to elevated levels of male sex hormones. Androgens can influence hepcidin regulation, potentially leading to increased hepcidin levels.

2. Iron Deficiency Anemia:

  • Symptoms: Emily’s symptoms of fatigue, irregular menstrual cycles, and hair loss are consistent with iron deficiency anemia, a condition characterized by insufficient iron levels for proper red blood cell production and function.

Treatment and Management:

Emily’s treatment plan includes:

1. PCOS Management:

  • Continuing with lifestyle modifications and hormonal therapy to manage her PCOS symptoms and hormone imbalances.

2. Iron Supplementation:

  • Initiating iron supplementation to correct the iron deficiency anemia. Iron supplementation should be tailored based on laboratory assessments, considering both iron status and hepcidin regulation.

3. Regular Monitoring:

  • Frequent monitoring of iron parameters, including serum ferritin, hemoglobin, and hepcidin levels, to assess the effectiveness of iron supplementation and make necessary adjustments.

4. Hormone Balancing:

  • Considering hormone-modulating therapies that address androgen levels in PCOS while being mindful of their potential influence on hepcidin regulation and iron metabolism.


This case study highlights the potential impact of hepcidin dysregulation in individuals with PCOS, a gonadal hormone disorder. Understanding the complex interactions between hormonal imbalances, hepcidin regulation, and anemia is crucial in managing this condition effectively. Tailored treatment strategies that address both PCOS-related issues and iron balance are essential for improving the health and quality of life of patients like Emily.

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